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CDK2 in complex with Cpd14 (5-fluoro-4-(4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl)-N-(5-(4-methylpiperazin-1-yl)pyridin-2-yl)pyrimidin-2-amine)

X-ray diffraction
2Å resolution
PDB entry 6oqi coloured by chain, front view.
PDB entry 6oqi coloured by chain, side view.
PDB entry 6oqi coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cyclin-dependent kinase 2
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Multimeric state: monomeric
Accessible surface area: 14082.8 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150313

Macromolecules

Cyclin-dependent kinase 2
Chain: A
Length: 299 amino acids
Theoretical weight: 34.12 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Pfam: Protein kinase domain
InterPro:
Cyclin-dependent kinase 2 in PDB entry 6oqi, assembly 1, front view.
Cyclin-dependent kinase 2 in PDB entry 6oqi, assembly 1, side view.
Cyclin-dependent kinase 2 in PDB entry 6oqi, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P24941  
129920406080100120140160180200220240260280
 
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UniProt
P24941
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