› 6owj

X-ray diffraction
1.94Å resolution

Zn-mediated polymerization of human SFPQ

Released:
DOI: 10.2210/pdb6owj/pdb
Model geometry
Data not analysed
Fit model/data
Data not analysed
PDB entry 6owj coloured by chain, front view.
PDB entry 6owj coloured by chain, side view.
PDB entry 6owj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of the zinc-induced cytoplasmic aggregation of the RNA-binding protein SFPQ.
Huang J, Ringuet M, Whitten AE, Caria S, Lim YW, Badhan R, Anggono V, Lee M
OpenAccess logo Nucleic Acids Res 48 3356-3365 (2020)
PMID: 32034402

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149903 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Splicing factor, proline- and glutamine-rich Chains: A, B
Molecule details ›
Chains: A, B
Length: 263 amino acids
Theoretical weight: 30.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P23246 (Residues: 276-535; Coverage: 37%)
Gene names: PSF, SFPQ
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 61.23Å b: 62.45Å c: 67.88Å
α: 90° β: 95.74° γ: 90°
R-values:
R R work R free
0.178 0.176 0.218
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Effect of metal ions on Alzheimer's disease.
Liu et al. (2022)
2 more

4 mentions without citation

The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration.
Lim et al. (2020)
3 more