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Cryo-EM structure of an Acinetobacter baumannii multidrug efflux pump

Electron Microscopy
2.98Å resolution
PDB entry 6ows coloured by chain, front view.
PDB entry 6ows coloured by chain, side view.
PDB entry 6ows coloured by chain, top view.
Source organism: Acinetobacter baumannii
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Efflux pump membrane transporter
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Multimeric state: homo trimer
Accessible surface area: 121940.46 Å2
Buried surface area: 22356.23 Å2
Dissociation area: 8,926.84 Å2
Dissociation energy (ΔGdiss): 100.66 kcal/mol
Dissociation entropy (TΔSdiss): 35.2 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-173394

Macromolecules

Efflux pump membrane transporter
Chains: A, B, C
Length: 1035 amino acids
Theoretical weight: 112.59 KDa
Source organism: Acinetobacter baumannii
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2FD70 (Residues: 2-1036; Coverage: 100%)
Gene names: 32_436, DWA16_01010, EA686_00900, GNY86_15955, adeB
Pfam: AcrB/AcrD/AcrF family
InterPro:
Efflux pump membrane transporter in PDB entry 6ows, assembly 1, front view.
Efflux pump membrane transporter in PDB entry 6ows, assembly 1, side view.
Efflux pump membrane transporter in PDB entry 6ows, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q2FD70  
110351002003004005006007008009001,000
 
5001000MSQFFIRRPVFAWVIAIFIIIFGLLSIPKLPIARFPSVAPPQVNISATYPGATAKTINDSVVTLIERELSGVKNLLYYSATTDTSGTAEITATFKPGTDVEMAQVDVQNKIKAVEARLPQVVRQQGLQVEASSSGFLMLVGINSPNNQYSEVDLSDYLVRNVVEELKRVEGVGKVQSFGAEKAMRIWVDPNKLVSYGLSISDVNNAIRENNVEIAPGRLGDLPAEKGQLITIPLSAQGQLSSLEQFKNISLKSKTNGSVIKLSDVANVEIGSQAYNFAILENGKPATAAAIQLSPGANAVKTAEGVRAKIEELKLNLPEGMEFSIPYDTAPFVKISIEKVIHTLLEAMVLVFIVMYLFLHNVRYTLIPAIVAPIALLGTFTVMLLAGFSINVLTMFGMVLAIGIIVDDAIVVVENVERIMATEGLSPKDATSKAMKEITSPIIGITLVLAAVFLPMAFASGSVGVIYKQFTLTMSVSILFSALLALILTPALCATILKPIDGHHQKKGFFAWFDRSFDKVTKKYELMLLKIIKHTVPMMVIFLVITGITFAGMKYWPTAFMPEEDQGWFMTSFQLPSDATAERTRNVVNQFENNLKDNPDVKSNTAILGWGFSGAGQNVAVAFTTLKDFKERTSSASKMTSDVNSSMANSTEGETMAVLPPAIDELGTFSGFSLRLQDRANLGMPALLAAQDELMAMAAKNKKFYMVWNEGLPQGDNISLKIDREKLSALGVKFSDVSDIISTSMGSMYINDFPNQGRMQQVIVQVEAKSRMQLKDILNLKVMGSSGQLVSLSEVVTPQWNKAPQQYNRYNGRPSLSIAGIPNFDTSSGEAMREMEQLIAKLPKGIGYEWTGISLQEKQSESQMAFLLGLSMLVVFLVLAALYESWAIPLSVMLVVPLGIFGAIIAIMSRGLMNDVFFKIGLITIIGLSAKNAILIVEFAKMLKEEGMSLIEATVAAAKLRLRPILMTSLAFTCGVIPLVIATGASSETQHALGTGVFGGMISATILAIFFVPVFFIFILGAVEKLFSSKKKISS
UniProt
Q2FD70
Chains
Domains
Secondary structure
Flexibility predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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