› 6p2d

X-ray diffraction
1.79Å resolution

Structure of mouse ketohexokinase-C in complex with fructose and ADP

Released:
DOI: 10.2210/pdb6p2d/pdb
PDB entry 6p2d coloured by chain, front view.
PDB entry 6p2d coloured by chain, side view.
PDB entry 6p2d coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Michaelis-like complex of mouse ketohexokinase isoform C
Gasper WC, Gardner S, Ross A, Oppelt SA, Allen KN, Tolan DR
Acta Crystallogr. D Biol. Crystallogr. (2024)

Function and Biology Details

Reaction catalysed: 
ATP + D-fructose = ADP + D-fructose 1-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161290 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ketohexokinase Chain: A
Molecule details ›
Chain: A
Length: 315 amino acids
Theoretical weight: 34.83 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P97328 (Residues: 2-298; Coverage: 100%)
Gene name: Khk
Sequence domains: pfkB family carbohydrate kinase

Ligands and Environments

3 bound ligands:
Ligand ADP 1 x ADP
Ligand FRU 1 x FRU
Ligand NO3 1 x NO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: C2221
Unit cell:
a: 42.252Å b: 78.446Å c: 150.772Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.17 0.22
Expression system: Escherichia coli BL21(DE3)

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