› 6p60

X-ray diffraction
2.5Å resolution

Vaccine-elicited NHP FP-targeting neutralizing antibody A12V163-a.02 in complex with HIV fusion peptide (residue 512-519)

Released:
DOI: 10.2210/pdb6p60/pdb
PDB entry 6p60 coloured by chain, front view.
PDB entry 6p60 coloured by chain, side view.
PDB entry 6p60 coloured by chain, top view.
Source organisms:
Entry authors: Xu K, Liu K, Kwong PD

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-209077 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Antibody A12V163-a.02 heavy chain Chains: A, C, G, J
Molecule details ›
Chains: A, C, G, J
Length: 225 amino acids
Theoretical weight: 24.08 KDa
Source organism: Platyrrhini
Expression system: Homo sapiens
Antibody A12V163-a.02 light chain Chains: B, D, H, K
Molecule details ›
Chains: B, D, H, K
Length: 212 amino acids
Theoretical weight: 22.49 KDa
Source organism: Platyrrhini
Expression system: Homo sapiens
Transmembrane protein gp41 Chains: E, F, I, L
Molecule details ›
Chains: E, F, I, L
Length: 8 amino acids
Theoretical weight: 733 Da
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P04578 (Residues: 512-519; Coverage: 1%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 77.784Å b: 72.199Å c: 185.526Å
α: 90° β: 96.63° γ: 90°
R-values:
R R work R free
0.197 0.196 0.209
Expression systems:
  • Homo sapiens
  • Not provided

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