› 6p6u

X-ray diffraction
2.42Å resolution

Crystal Structure of Monoclinic Rabbit Muscle Lactate Dehydrogenase with Four Tetramers as the Asymmetric Unit

Released:
DOI: 10.2210/pdb6p6u/pdb
PDB entry 6p6u coloured by chain, front view.
PDB entry 6p6u coloured by chain, side view.
PDB entry 6p6u coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Entry author: McPherson A

Function and Biology Details

Reaction catalysed: 
(S)-lactate + NAD(+) = pyruvate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L-lactate dehydrogenase A chain Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Length: 332 amino acids
Theoretical weight: 36.61 KDa
Source organism: Oryctolagus cuniculus
Expression system: Oryctolagus cuniculus
UniProt:
  • Canonical: P13491 (Residues: 1-332; Coverage: 100%)
Gene name: LDHA
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand AMP 2 x AMP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 160.572Å b: 100.838Å c: 223.102Å
α: 90° β: 101.23° γ: 90°
R-values:
R R work R free
0.184 0.181 0.213
Expression system: Oryctolagus cuniculus

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