› 6p7f

X-ray diffraction
2.85Å resolution

Human ABCC6 NBD2 R1459D mutant in Apo state

Released:
DOI: 10.2210/pdb6p7f/pdb
PDB entry 6p7f coloured by chain, front view.
PDB entry 6p7f coloured by chain, side view.
PDB entry 6p7f coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zheng A, Thibodeau PH

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + glutathione-S-conjugate(Side 1) = ADP + phosphate + glutathione-S-conjugate(Side 2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131867 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-binding cassette sub-family C member 6 Chain: A
Molecule details ›
Chain: A
Length: 250 amino acids
Theoretical weight: 27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95255 (Residues: 1254-1503; Coverage: 17%)
Gene names: ABCC6, ARA, MRP6
Sequence domains: ABC transporter

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P41212
Unit cell:
a: 99.34Å b: 99.34Å c: 84Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.264 0.262 0.289
Expression system: Escherichia coli

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