› 6paw

X-ray diffraction
2.95Å resolution

Crystal structure of DAPK2 S308A Calcium/Calmodulin complex

Released:
DOI: 10.2210/pdb6paw/pdb
PDB entry 6paw coloured by chain, front view.
PDB entry 6paw coloured by chain, side view.
PDB entry 6paw coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Simon B, Wilmanns M

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-534460 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Death-associated protein kinase 2 Chains: A, B, E, F
Molecule details ›
Chains: A, B, E, F
Length: 323 amino acids
Theoretical weight: 37.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9UIK4 (Residues: 12-330; Coverage: 86%)
Gene name: DAPK2
Sequence domains: Protein kinase domain
Calmodulin-1 Chains: C, D, G, H
Molecule details ›
Chains: C, D, G, H
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P0DP23 (Residues: 1-149; Coverage: 100%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair

Ligands and Environments

1 bound ligand:
Ligand CA 9 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
Spacegroup: P212121
Unit cell:
a: 89.44Å b: 95.88Å c: 263.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.251 0.249 0.288
Expression system: Escherichia coli BL21

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