› 6ped

X-ray diffraction
2.3Å resolution

Crystal structure of HEMK2-TRMT112 complex

Released:
DOI: 10.2210/pdb6ped/pdb
PDB entry 6ped coloured by chain, front view.
PDB entry 6ped coloured by chain, side view.
PDB entry 6ped coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dong C, Tempel W, Bountra C, Arrowsmith CH, Edwards AM, Min J, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193774 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Methyltransferase N6AMT1 Chain: A
Molecule details ›
Chain: A
Length: 233 amino acids
Theoretical weight: 25.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y5N5 (Residues: 1-214; Coverage: 100%)
Gene names: C21orf127, HEMK2, KMT9, N6AMT1, PRED28
Sequence domains: Methyltransferase small domain
Multifunctional methyltransferase subunit TRM112-like protein Chain: B
Molecule details ›
Chain: B
Length: 143 amino acids
Theoretical weight: 16.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UI30 (Residues: 1-125; Coverage: 100%)
Gene names: AD-001, HSPC152, HSPC170, TRMT112
Sequence domains: Trm112p-like protein

Ligands and Environments

2 bound ligands:
Ligand SAH 1 x SAH
Ligand UNX 12 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P6122
Unit cell:
a: 110.539Å b: 110.539Å c: 131.972Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.192 0.242
Expression system: Escherichia coli BL21(DE3)

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