› 6pfm

X-ray diffraction
2.84Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136919 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor Chains: A, D
Molecule details ›
Chains: A, D
Length: 280 amino acids
Theoretical weight: 31.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 298-553; Coverage: 43%)
  • Best match: P03372-2 (Residues: 254-441)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:
Ligand OGJ 2 x OGJ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: R32
Unit cell:
a: 144.106Å b: 144.106Å c: 171.064Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.211 0.209 0.249
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Oral Selective Estrogen Receptor Degraders (SERDs) as a Novel Breast Cancer Therapy: Present and Future from a Clinical Perspective.
Hernando et al. (2021)
1 more

3 mentions without citation

Computer-Aided Ligand Discovery for Estrogen Receptor Alpha.
Bafna et al. (2020)
2 more