› 6pok

X-ray diffraction
1.8Å resolution

Crystal structure of the Robo3 FN2-3 domains

Released:
DOI: 10.2210/pdb6pok/pdb
PDB entry 6pok coloured by chain, front view.
PDB entry 6pok coloured by chain, side view.
PDB entry 6pok coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance.
Pak JS, DeLoughery ZJ, Wang J, Acharya N, Park Y, Jaworski A, Özkan E
OpenAccess logo Nat Commun 11 1489 (2020)
PMID: 32198364

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188632 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Roundabout homolog 3 Chain: A
Molecule details ›
Chain: A
Length: 213 amino acids
Theoretical weight: 22.49 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q96MS0 (Residues: 664-870; Coverage: 15%)
Gene name: ROBO3
Sequence domains: Fibronectin type III domain

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 54.986Å b: 36.607Å c: 64.896Å
α: 90° β: 114.44° γ: 90°
R-values:
R R work R free
0.218 0.217 0.243
Expression system: Trichoplusia ni

Quick links

Citations

7 review citations

New insights into the molecular mechanisms of axon guidance receptor regulation and signaling.
Zang et al. (2021)
6 more