› 6pv3

Solution NMR

Backbone-modified variant of zinc finger 2 from the transcription factor Sp1 DNA binding domain: altered helix, loop, turn, and sheet

Released:
DOI: 10.2210/pdb6pv3/pdb
PDB entry 6pv3 coloured by chain, ensemble of 10 models, front view.
PDB entry 6pv3 coloured by chain, ensemble of 10 models, side view.
PDB entry 6pv3 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Proteomimetic Zinc Finger Domains with Modified Metal-binding β-Turns.
Rao SR, Horne WS
Pept Sci (Hoboken) 112 (2020)
PMID: 33733039

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139897 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription factor Sp1 Chain: A
Molecule details ›
Chain: A
Length: 31 amino acids
Theoretical weight: 3.65 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P08047 (Residues: 655-684; Coverage: 4%)
Gene names: SP1, TSFP1
Sequence domains: Zinc finger, C2H2 type

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
5 modified residues:
Ligand AIB 1 x AIB
Ligand MMO 1 x MMO
Ligand B3D 1 x B3D
Ligand HMR 2 x HMR
Ligand B3T 1 x B3T

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 50%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

3 review citations

Studying Peptide-Metal Ion Complex Structures by Solution-State NMR.
Shalev DE. (2022)
2 more

3 mentions without citation

Metal-Binding Foldamers.
Rao et al. (2021)
2 more