› 6pwz

X-ray diffraction
3Å resolution

Crystal structure of human uridine-cytidine kinase 2 complexed with 2'-azidocytidine

Released:
DOI: 10.2210/pdb6pwz/pdb
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PDB entry 6pwz coloured by chain, front view.
PDB entry 6pwz coloured by chain, side view.
PDB entry 6pwz coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Cuthbert BJ, Goulding CW

Function and Biology Details

Reaction catalysed: 
ATP + cytidine = ADP + CMP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189869 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uridine-cytidine kinase 2 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 250 amino acids
Theoretical weight: 28.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BZX2 (Residues: 1-250; Coverage: 96%)
Gene names: UCK2, UMPK
Sequence domains: Phosphoribulokinase / Uridine kinase family

Ligands and Environments

3 bound ligands:
Ligand PO4 8 x PO4
Ligand GOL 30 x GOL
Ligand P6D 3 x P6D
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21
Unit cell:
a: 93.73Å b: 84.74Å c: 153.579Å
α: 90° β: 95.36° γ: 90°
R-values:
R R work R free
0.199 0.197 0.254
Expression system: Escherichia coli

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