› 6px7

Solution NMR

Dg12a in Weaponisation 'on the fly': Convergent recruitment of knottin and defensin scaffolds as neurotoxins in the venom of assassin fly Dolopus genitalis (Diptera: Asilidae)

Released:
DOI: 10.2210/pdb6px7/pdb
PDB entry 6px7 coloured by chain, ensemble of 20 models, front view.
PDB entry 6px7 coloured by chain, ensemble of 20 models, side view.
PDB entry 6px7 coloured by chain, ensemble of 20 models, top view.
Source organism: Dolopus genitalis
Primary publication:
Weaponisation 'on the fly': Convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies.
Jin J, Agwa AJ, Szanto TG, Csóti A, Panyi G, Schroeder CI, Walker AA, King GF
Insect Biochem Mol Biol 118 103310 (2020)
PMID: 31870846

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-104878 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
U-Asilidin(1)-Dg12 Chain: A
Molecule details ›
Chain: A
Length: 34 amino acids
Theoretical weight: 3.92 KDa
Source organism: Dolopus genitalis
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A3G5BIC2 (Residues: 47-80; Coverage: 61%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 81%
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

5 citation in other articles

An Appetite for Destruction: Detecting Prey-Selective Binding of α-Neurotoxins in the Venom of Afro-Asian Elapids.
Harris et al. (2020)
4 more