› 6py0

X-ray diffraction
2.2Å resolution

Crystal Structure of mouse Serum Amyloid A3 (SAA3) bound with Retinol

Released:
DOI: 10.2210/pdb6py0/pdb
PDB entry 6py0 coloured by chain, front view.
PDB entry 6py0 coloured by chain, side view.
PDB entry 6py0 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Molecular basis for retinol binding by serum amyloid A during infection.
Hu Z, Bang YJ, Ruhn KA, Hooper LV
OpenAccess logo Proc Natl Acad Sci U S A 116 19077-19082 (2019)
PMID: 31484771

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138264 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serum amyloid A-3 protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 104 amino acids
Theoretical weight: 11.92 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P04918 (Residues: 19-122; Coverage: 100%)
Gene name: Saa3
Sequence domains: Serum amyloid A protein

Ligands and Environments

1 bound ligand:
Ligand RTL 1 x RTL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 53.242Å b: 75.749Å c: 89.263Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.218 0.249
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Structural Basis for Vital Function and Malfunction of Serum Amyloid A: an Acute-Phase Protein that Wears Hydrophobicity on Its Sleeve.
Gursky O. (2020)
6 more

3 mentions without citation

Dynamic protein structures in normal function and pathologic misfolding in systemic amyloidosis.
Lewkowicz et al. (2022)
2 more