› 6q7c

X-ray diffraction
1.05Å resolution

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with the NVP-BHG712 derivative ATDL11

Released:
DOI: 10.2210/pdb6q7c/pdb
PDB entry 6q7c coloured by chain, front view.
PDB entry 6q7c coloured by chain, side view.
PDB entry 6q7c coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kudlinzki D, Troester A, Witt K, Linhard VL, Gande SL, Saxena K, Schwalbe H

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151387 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 34.46 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29317 (Residues: 596-900; Coverage: 32%)
Gene names: ECK, EPHA2
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
Ligand HOK 1 x HOK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: P21
Unit cell:
a: 32.758Å b: 106.115Å c: 40.301Å
α: 90° β: 108.95° γ: 90°
R-values:
R R work R free
0.193 0.192 0.212
Expression system: Spodoptera frugiperda

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