6qb6

X-ray diffraction
2.24Å resolution

Mcl1 in complex with a Fab

Released:
Model geometry
Fit model/data

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-280155 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Induced myeloid leukemia cell differentiation protein Mcl-1 Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 18.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07820 (Residues: 174-327; Coverage: 44%)
Gene names: BCL2L3, MCL1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Fab Heavy Chain Chain: H
Molecule details ›
Chain: H
Length: 230 amino acids
Theoretical weight: 24.49 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Fab Light Chain Chain: L

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2
Unit cell:
a: 148.05Å b: 42.46Å c: 106.23Å
α: 90° β: 113.19° γ: 90°
R-values:
R R work R free
0.19 0.187 0.232
Expression systems:
  • Escherichia coli
  • Cricetulus griseus