› 6qey

X-ray diffraction
2.2Å resolution

IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties

Released:
DOI: 10.2210/pdb6qey/pdb
PDB entry 6qey coloured by chain, front view.
PDB entry 6qey coloured by chain, side view.
PDB entry 6qey coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties.
Dagil R, Ball NJ, Ogrodowicz RW, Hobor F, Purkiss AG, Kelly G, Martin SR, Taylor IA, Ramos A
OpenAccess logo Nucleic Acids Res 47 4334-4348 (2019)
PMID: 30864660

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-576475 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor 2 mRNA-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 179 amino acids
Theoretical weight: 19.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZI8 (Residues: 194-369; Coverage: 31%)
Gene names: CRDBP, IGF2BP1, VICKZ1, ZBP1
Sequence domains: KH domain

Ligands and Environments

2 bound ligands:
Ligand CCN 1 x CCN
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 41.421Å b: 32.987Å c: 58.721Å
α: 90° β: 103.14° γ: 90°
R-values:
R R work R free
0.184 0.181 0.246
Expression system: Escherichia coli

Quick links

Citations

3 review citations

KH domain proteins: Another family of bacterial RNA matchmakers?
Olejniczak et al. (2022)
2 more

6 mentions without citation

Characterization of epitranscriptome reader proteins experimentally and in silico: Current knowledge and future perspectives beyond the YTH domain.
Miller et al. (2023)
5 more