› 6qjl

X-ray diffraction
1.04Å resolution

Crystal Structure of the third PDZ domain of PSD-95 protein D332G mutant: space group P21

Released:
DOI: 10.2210/pdb6qjl/pdb
PDB entry 6qjl coloured by chain, front view.
PDB entry 6qjl coloured by chain, side view.
PDB entry 6qjl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational changes in the third PDZ domain of the neuronal postsynaptic density protein 95.
Camara-Artigas A, Murciano-Calles J, Martínez JC
Acta Crystallogr D Struct Biol 75 381-391 (2019)
PMID: 30988255

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160251 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disks large homolog 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 104 amino acids
Theoretical weight: 11.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P78352 (Residues: 302-403; Coverage: 14%)
Gene names: DLG4, PSD95
Sequence domains: PDZ domain

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P21
Unit cell:
a: 41.313Å b: 47.023Å c: 43.253Å
α: 90° β: 92.19° γ: 90°
R-values:
R R work R free
0.153 0.152 0.174
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

The Conformational Plasticity Vista of PDZ Domains.
Murciano-Calles J. (2020)
3 other articles

1 mention without citation

Correspondence between functional scores from deep mutational scans and predicted effects on protein stability.
Gerasimavicius et al. (2023)