6qkc

Electron Microscopy
4.4Å resolution

GluA1/2 In complex with auxiliary subunit gamma-8

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-539149 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Glutamate receptor 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 915 amino acids
Theoretical weight: 102.66 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19490 (Residues: 1-19, 20-907; Coverage: 100%)
  • Best match: P19490-2 (Residues: 1-19, 20-907)
Gene names: GluA1, Glur1, Gria1
Sequence domains:
Glutamate receptor 2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 860 amino acids
Theoretical weight: 96.25 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 1-860; Coverage: 97%)
  • Best match: P19491-2 (Residues: 1-860)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Voltage-dependent calcium channel gamma-8 subunit Chains: I, J
Molecule details ›
Chains: I, J
Length: 423 amino acids
Theoretical weight: 43.58 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8VHW5 (Residues: 2-417; Coverage: 99%)
Gene name: Cacng8
Sequence domains: PMP-22/EMP/MP20/Claudin family

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.4Å
Relevant EMDB volumes: EMD-4572
Expression system: Homo sapiens