Function and Biology Details
Reactions catalysed:
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH
Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]
Acetyl-CoA + n malonyl-CoA + 2n NADPH = long-chain-acyl-CoA + n CoA + n CO(2) + 2n NADP(+)
An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH
Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein]
Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein]
Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate
A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero octadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139407 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fatty acid synthase subunit alpha
Molecule details ›
Chains: A, B, C, D, E, F
Length: 1887 amino acids
Theoretical weight: 207.18 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
Sequence domains:
Length: 1887 amino acids
Theoretical weight: 207.18 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
- Canonical:
P19097 (Residues: 1-1887; Coverage: 100%)
Sequence domains:
Fatty acid synthase subunit beta
Molecule details ›
Chains: G, H, I, J, K, L
Length: 2040 amino acids
Theoretical weight: 227.79 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
Sequence domains:
Length: 2040 amino acids
Theoretical weight: 227.79 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
- Canonical: P07149 (Residues: 5-2050; Coverage: 100%)
Sequence domains:
- N-terminal domain in fatty acid synthase subunit beta
- Starter unit:ACP transacylase in aflatoxin biosynthesis
- Fatty acid synthase subunit beta/Fas1-like, helical
- Fatty acid synthase meander beta sheet domain
- N-terminal half of MaoC dehydratase
- Fatty acid synthase subunit beta, insertion domain
- MaoC like domain
- Acyl transferase domain
Translation machinery-associated protein 17
Molecule details ›
Chains: M, N, O, P, Q, R
Length: 148 amino acids
Theoretical weight: 16.56 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
Length: 148 amino acids
Theoretical weight: 16.56 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
- Canonical: Q12513 (Residues: 3-150; Coverage: 99%)
