› 6r3d

X-ray diffraction
1.85Å resolution

Crystal structure of di-phosphorylated human CLK1 in complex with 4-(6,7-dichloro-1H-indol-3-yl)pyrimidin-2-amine

Released:
DOI: 10.2210/pdb6r3d/pdb
PDB entry 6r3d coloured by chain, front view.
PDB entry 6r3d coloured by chain, side view.
PDB entry 6r3d coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Livnah O, Domovich Y

Function and Biology Details

Reaction catalysed: 
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156010 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity protein kinase CLK1 Chain: A
Molecule details ›
Chain: A
Length: 337 amino acids
Theoretical weight: 39.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49759 (Residues: 148-484; Coverage: 70%)
Gene names: CLK, CLK1
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
Ligand JQW 1 x JQW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P6522
Unit cell:
a: 68.622Å b: 68.622Å c: 285.132Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.223 0.221 0.265
Expression system: Escherichia coli

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