› › Function and Biology

Structure of a truncated adenylyl cyclase bound to MANT-GTP, forskolin and an activated stimulatory Galphas protein

Source organism: Bos taurus
Biochemical function: G-protein beta/gamma-subunit complex binding
Biological process: G protein-coupled receptor signaling pathway
Cellular component: ciliary basal body

Quick links

EC 4.6.1.1: Adenylate cyclase

Reaction catalysed:
ATP = 3',5'-cyclic AMP + diphosphate
Systematic name:
ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
Alternative Name(s):
  • 3',5'-cyclic AMP synthetase
  • ATP diphosphate-lyase (cyclizing)
  • ATP pyrophosphate-lyase
  • Adenyl cyclase
  • Adenylyl cyclase
  • Adenylylcyclase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00211
Domain description: Adenylate and Guanylate cyclase catalytic domain
Occurring in:
  1. adenylate cyclase
The deposited structure of PDB entry 6r4o contains 2 copies of Pfam domain PF00211 (Adenylate and Guanylate cyclase catalytic domain) in adenylate cyclase. Showing 2 copies in chain A.

PF00503
Domain description: G-protein alpha subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
The deposited structure of PDB entry 6r4o contains 1 copy of Pfam domain PF00503 (G-protein alpha subunit) in Guanine nucleotide-binding protein G(s) subunit alpha isoforms short. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000786
Domain description: Green fluorescent protein, GFP
Occurring in:
  1. adenylate cyclase
IPR001019
Domain description: Guanine nucleotide binding protein (G-protein), alpha subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR001054
Domain description: Adenylyl cyclase class-3/4/guanylyl cyclase
Occurring in:
  1. adenylate cyclase
IPR000367
Domain description: G-protein alpha subunit, group S
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR029787
Domain description: Nucleotide cyclase
Occurring in:
  1. adenylate cyclase
IPR009017
Domain description: Green fluorescent protein
Occurring in:
  1. adenylate cyclase
IPR011025
Domain description: G protein alpha subunit, helical insertion
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR018297
Domain description: Adenylyl cyclase class-4/guanylyl cyclase, conserved site
Occurring in:
  1. adenylate cyclase
IPR011584
Domain description: Green fluorescent protein-related
Occurring in:
  1. adenylate cyclase

Quick links