› 6r4r

Electron Microscopy
3.4Å resolution

Cryo-EM Structure of the PI3-Kinase SH3 Domain Amyloid Fibril

Released:
DOI: 10.2210/pdb6r4r/pdb
PDB entry 6r4r coloured by chain, front view.
PDB entry 6r4r coloured by chain, side view.
PDB entry 6r4r coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy.
Röder C, Vettore N, Mangels LN, Gremer L, Ravelli RBG, Willbold D, Hoyer W, Buell AK, Schröder GF
OpenAccess logo Nat Commun 10 3754 (2019)
PMID: 31434882
Related structures: EMD-4727

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150055 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 86 amino acids
Theoretical weight: 9.65 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P23727 (Residues: 1-84; Coverage: 12%)
Gene name: PIK3R1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-4727
Expression system: Escherichia coli BL21

Quick links

Citations

7 review citations

General Principles Underpinning Amyloid Structure.
Taylor et al. (2022)
6 more