› 6rcy

X-ray diffraction
2.3Å resolution

CRYSTAL STRUCTURE OF FK1 DOMAIN OF FKBP52 IN COMPLEX WITH A BIO-INSPIRED HYBRID FLUORESCENT LIGAND

Released:
DOI: 10.2210/pdb6rcy/pdb
PDB entry 6rcy coloured by chain, front view.
PDB entry 6rcy coloured by chain, side view.
PDB entry 6rcy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Bioinspired Hybrid Fluorescent Ligands for the FK1 Domain of FKBP52.
de la Sierra-Gallay IL, Belnou M, Chambraud B, Genet M, van Tilbeurgh H, Aumont-Nicaise M, Desmadril M, Baulieu EE, Jacquot Y, Byrne C
J Med Chem 63 10330-10338 (2020)
PMID: 32866001

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169761 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 16.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02790 (Residues: 1-148; Coverage: 32%)
Gene names: FKBP4, FKBP52
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase

Ligands and Environments

1 bound ligand:
Ligand K0T 1 x K0T
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: P6522
Unit cell:
a: 52.96Å b: 52.96Å c: 237.86Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.22 0.218 0.244
Expression system: Escherichia coli

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