› 6rmn

X-ray diffraction
2.2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153773 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA mismatch repair protein MLH1 Chain: A
Molecule details ›
Chain: A
Length: 265 amino acids
Theoretical weight: 30.76 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
  • Canonical: P38920 (Residues: 505-769; Coverage: 35%)
Gene names: MLH1, PMS2, YM8520.16, YMR167W
Sequence domains: DNA mismatch repair protein Mlh1 C-terminus
DNA mismatch repair protein MLH3 Chain: B
Molecule details ›
Chain: B
Length: 238 amino acids
Theoretical weight: 27.64 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12083 (Residues: 477-714; Coverage: 33%)
Gene names: MLH3, P2550, YPL164C

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: I222
Unit cell:
a: 92.26Å b: 104.36Å c: 135.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.197 0.226
Expression system: Escherichia coli

Quick links

Citations

9 citation in other articles

Cilia regulate meiotic recombination in zebrafish.
Xie et al. (2022)
8 more

1 mention without citation

The Dmc1 recombinase physically interacts with and promotes the meiotic crossover functions of the Mlh1-Mlh3 endonuclease.
Pannafino et al. (2023)