› 6rpv

Hybrid

Extremely stable monomeric variant of human cystatin C with single amino acid substitution

Released:
DOI: 10.2210/pdb6rpv/pdb
PDB entry 6rpv coloured by chain, ensemble of 20 models, front view.
PDB entry 6rpv coloured by chain, ensemble of 20 models, side view.
PDB entry 6rpv coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR and crystallographic structural studies of the extremely stable monomeric variant of human cystatin C with single amino acid substitution.
Maszota-Zieleniak M, Jurczak P, Orlikowska M, Zhukov I, Borek D, Otwinowski Z, Skowron P, Pietralik Z, Kozak M, Szymańska A, Rodziewicz-Motowidło S
FEBS J 287 361-376 (2020)
PMID: 31330077

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133888 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cystatin-C Chain: A
Molecule details ›
Chain: A
Length: 120 amino acids
Theoretical weight: 13.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01034 (Residues: 27-146; Coverage: 100%)
Gene name: CST3
Sequence domains: Cystatin domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Experimental Method: X-ray solution scattering, Solution NMR
Expression system: Escherichia coli

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Citations

4 citation in other articles

Maturation of the functional mouse CRES amyloid from globular form.
Hewetson et al. (2020)
3 more

4 mentions without citation

NMR and crystallographic structural studies of the extremely stable monomeric variant of human cystatin C with single amino acid substitution.
Maszota-Zieleniak et al. (2020)
3 more