6rqc

Electron Microscopy
4.4Å resolution

Cryo-EM structure of an MCM loading intermediate

Released:
Related structures: EMD-4980

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetradecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-120568 (preferred)
Entry contents:
12 distinct polypeptide molecules
2 distinct DNA molecules
Macromolecules (14 distinct):
Origin recognition complex subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 949 amino acids
Theoretical weight: 108.61 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: P54784 (Residues: 1-914; Coverage: 100%)
Gene names: ORC1, YML065W
Sequence domains:
Origin recognition complex subunit 2 Chain: B
Molecule details ›
Chain: B
Length: 620 amino acids
Theoretical weight: 71.34 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: P32833 (Residues: 1-620; Coverage: 100%)
Gene names: ORC2, RRR1, SIR5, YBR0523, YBR060C
Sequence domains: Origin recognition complex subunit 2
Origin recognition complex subunit 3 Chain: C
Origin recognition complex subunit 4 Chain: D
Origin recognition complex subunit 5 Chain: E
Origin recognition complex subunit 6 Chain: F
DNA replication licensing factor MCM2 Chain: 2
DNA replication licensing factor MCM3 Chain: 3
DNA replication licensing factor MCM4 Chain: 4
Minichromosome maintenance protein 5 Chain: 5
DNA replication licensing factor MCM6 Chain: 6
DNA replication licensing factor MCM7 Chain: 7
DNA (88-MER) Chain: X
DNA (88-MER) Chain: Y

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.4Å
Relevant EMDB volumes: EMD-4980
Expression system: Saccharomyces cerevisiae S288C