Function and Biology Details
Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Influenza RNA-dependent RNA polymerase subunit PB1
- PB2, C-terminal
- Influenza RNA-dependent RNA polymerase subunit PB2
- RNA-directed RNA polymerase, negative-strand RNA virus
- Influenza RNA-dependent RNA polymerase subunit PA
- Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain
- Polymerase acidic protein
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-137009 (preferred)
Entry contents:
3 distinct polypeptide molecules
3 distinct RNA molecules
3 distinct RNA molecules
Macromolecules (6 distinct):
Polymerase acidic protein
Molecule details ›
Chain: A
Length: 716 amino acids
Theoretical weight: 83.1 KDa
Source organism: Influenza A virus (A/nt/60/1968(H3N2))
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA
Length: 716 amino acids
Theoretical weight: 83.1 KDa
Source organism: Influenza A virus (A/nt/60/1968(H3N2))
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P03434 (Residues: 1-716; Coverage: 100%)
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA
RNA-directed RNA polymerase catalytic subunit
Molecule details ›
Chain: B
Length: 757 amino acids
Theoretical weight: 86.52 KDa
Source organism: Influenza A virus (A/nt/60/1968(H3N2))
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PB1
Length: 757 amino acids
Theoretical weight: 86.52 KDa
Source organism: Influenza A virus (A/nt/60/1968(H3N2))
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P03432 (Residues: 1-757; Coverage: 100%)
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PB1
Polymerase basic protein 2
Molecule details ›
Chain: C
Length: 765 amino acids
Theoretical weight: 86.96 KDa
Source organism: Influenza A virus (A/nt/60/1968(H3N2))
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 765 amino acids
Theoretical weight: 86.96 KDa
Source organism: Influenza A virus (A/nt/60/1968(H3N2))
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P03429 (Residues: 1-759; Coverage: 100%)
Sequence domains:
- Influenza RNA polymerase PB2 N-terminal region
- Influenza RNA polymerase PB2 second domain
- Influenza RNA polymerase PB2 middle domain
- Influenza RNA polymerase PB2 helical domain
- Influenza RNA polymerase PB2 CAP binding domain
- Influenza RNA polymerase PB2 6th domain
- Influenza RNA polymerase PB2 C-terminal domain
