› 6rrl

Solution NMR

Solution NMR structure of the peptide 3967 from medicinal leech Hirudo medicinalis in dodecylphosphocholine micelles

Released:
DOI: 10.2210/pdb6rrl/pdb
PDB entry 6rrl coloured by chain, ensemble of 20 models, front view.
PDB entry 6rrl coloured by chain, ensemble of 20 models, side view.
PDB entry 6rrl coloured by chain, ensemble of 20 models, top view.
Source organism: Hirudo medicinalis
Primary publication:
Medicinal leech antimicrobial peptides lacking toxicity represent a promising alternative strategy to combat antibiotic-resistant pathogens.
Grafskaia EN, Nadezhdin KD, Talyzina IA, Polina NF, Podgorny OV, Pavlova ER, Bashkirov PV, Kharlampieva DD, Bobrovsky PA, Latsis IA, Manuvera VA, Babenko VV, Trukhan VM, Arseniev AS, Klinov DV, Lazarev VN
Eur J Med Chem 180 143-153 (2019)
PMID: 31302447

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-167404 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
peptide 3967 Chain: A
Molecule details ›
Chain: A
Length: 12 amino acids
Theoretical weight: 1.56 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment: 71%
Refinement method: torsion angle dynamics
Expression system: Not provided

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Citations

3 review citations

Synergies with and Resistance to Membrane-Active Peptides.
Kmeck et al. (2020)
2 more

2 mentions without citation

Characterization of the structure-function relationship of a novel salt-resistant antimicrobial peptide, RR12.
Wu et al. (2020)
1 more