› 6rvy

Electron Microscopy
4.13Å resolution

Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in absence of substrate

Released:
DOI: 10.2210/pdb6rvy/pdb
PDB entry 6rvy coloured by chain, front view.
PDB entry 6rvy coloured by chain, side view.
PDB entry 6rvy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2.
Garaeva AA, Guskov A, Slotboom DJ, Paulino C
OpenAccess logo Nat Commun 10 3427 (2019)
PMID: 31366933
Related structures: EMD-10018

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172390 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutral amino acid transporter B(0) Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 547 amino acids
Theoretical weight: 57.52 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q15758 (Residues: 1-541; Coverage: 100%)
Gene names: ASCT2, M7V1, RDR, RDRC, SLC1A5
Sequence domains: Sodium:dicarboxylate symporter family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.13Å
Relevant EMDB volumes: EMD-10018
Expression system: Komagataella pastoris

Quick links

Citations

8 review citations

Advances and Challenges in Rational Drug Design for SLCs.
Garibsingh et al. (2019)
7 more

5 mentions without citation

Elevator-type mechanisms of membrane transport.
Garaeva et al. (2020)
4 more