› 6rw0

X-ray diffraction
1.45Å resolution

Crystal structure of ANGEL2, a 2',3'-cyclic phosphatase

Released:
DOI: 10.2210/pdb6rw0/pdb
PDB entry 6rw0 coloured by chain, front view.
PDB entry 6rw0 coloured by chain, side view.
PDB entry 6rw0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
Pinto PH, Kroupova A, Schleiffer A, Mechtler K, Jinek M, Weitzer S, Martinez J
Science 369 524-530 (2020)
PMID: 32732418

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-562653 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein angel homolog 2 Chain: A
Molecule details ›
Chain: A
Length: 429 amino acids
Theoretical weight: 48.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q5VTE6 (Residues: 119-544; Coverage: 78%)
Gene names: ANGEL2, KIAA0759L
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand MG 1 x MG
Ligand K 2 x K
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P3121
Unit cell:
a: 98.401Å b: 98.401Å c: 93.342Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.133 0.132 0.156
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

Detecting and Rescuing Stalled Ribosomes.
Yip et al. (2021)
4 more

1 mention without citation

Interaction of Vanadium Complexes with Proteins: Revisiting the Reported Structures in the Protein Data Bank (PDB) since 2015.
Santos et al. (2023)