› 6rx7

X-ray diffraction
1.63Å resolution

Structure of the KIV type 2 (KIV-2) domain of lipoprotein (a)

Released:
DOI: 10.2210/pdb6rx7/pdb
PDB entry 6rx7 coloured by chain, front view.
PDB entry 6rx7 coloured by chain, side view.
PDB entry 6rx7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High resolution structure of human apolipoprotein (a) kringle IV type 2: beyond the lysine binding site.
Santonastaso A, Maggi M, De Jonge H, Scotti C
J Lipid Res 61 1687-1696 (2020)
PMID: 32907988

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140162 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apolipoprotein(a) Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 111 amino acids
Theoretical weight: 12.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08519 (Residues: 701-796; Coverage: 5%)
Gene name: LPA
Sequence domains: Kringle domain

Ligands and Environments

2 bound ligands:
Ligand GOL 8 x GOL
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: C2
Unit cell:
a: 120.246Å b: 42.839Å c: 61.175Å
α: 90° β: 110.23° γ: 90°
R-values:
R R work R free
0.234 0.232 0.269
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Evidence and Uncertainties on Lipoprotein(a) as a Marker of Cardiovascular Health Risk in Children and Adolescents.
Genovesi et al. (2023)
2 more

2 mentions without citation

High resolution structure of human apolipoprotein (a) kringle IV type 2: beyond the lysine binding site.
Santonastaso et al. (2020)
1 more