› 6s0b

X-ray diffraction
2.31Å resolution

Crystal Structure of Properdin in complex with the CTC domain of C3/C3b

Released:
DOI: 10.2210/pdb6s0b/pdb
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PDB entry 6s0b coloured by chain, front view.
PDB entry 6s0b coloured by chain, side view.
PDB entry 6s0b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b.
van den Bos RM, Pearce NM, Granneman J, Brondijk THC, Gros P
OpenAccess logo Front Immunol 10 2097 (2019)
PMID: 31552043

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133846 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Properdin Chain: A
Molecule details ›
Chain: A
Length: 225 amino acids
Theoretical weight: 25.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P27918 (Residues: 256-469; Coverage: 48%)
Gene names: CFP, PFC
Sequence domains:
Properdin Chain: B
Molecule details ›
Chain: B
Length: 110 amino acids
Theoretical weight: 11.89 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P27918 (Residues: 26-132; Coverage: 24%)
Gene names: CFP, PFC
Sequence domains:
Complement C3c alpha' chain fragment 2 Chain: C

Ligands and Environments

Carbohydrate polymer : NEW Components: FUC, BGC
Carbohydrate polymer
2 bound ligands:
Ligand MAN 8 x MAN
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 71.471Å b: 71.497Å c: 134.182Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.23 0.277
Expression system: Homo sapiens

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Citations

3 review citations

Protein C-Mannosylation and C-Mannosyl Tryptophan in Chemical Biology and Medicine.
Minakata et al. (2021)
2 more

5 mentions without citation

Complement component C3: A structural perspective and potential therapeutic implications.
Geisbrecht et al. (2022)
4 more

PDB-REDO

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