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Human polymerase delta holoenzyme Conformer 3

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: DNA repair
Cellular component: nucleoplasm

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EC 2.7.7.7: DNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • DNA duplicase
  • DNA nucleotidyltransferase
  • DNA nucleotidyltransferase (DNA-directed)
  • DNA polymerase
  • DNA polymerase I
  • DNA polymerase II
  • DNA polymerase III
  • DNA polymerase alpha
  • DNA polymerase beta
  • DNA polymerase gamma
  • DNA replicase
  • DNA-dependent DNA polymerase
  • Deoxynucleate polymerase
  • Deoxyribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid duplicase
  • Deoxyribonucleic acid polymerase
  • Deoxyribonucleic duplicase
  • Deoxyribonucleic polymerase
  • Deoxyribonucleic polymerase I
  • Duplicase
  • Klenow fragment
  • Sequenase
  • Taq DNA polymerase
  • Taq Pol I
  • Tca DNA polymerase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF02747
Domain description: Proliferating cell nuclear antigen, C-terminal domain
Occurring in:
  1. Proliferating cell nuclear antigen
The deposited structure of PDB entry 6s1o contains 3 copies of Pfam domain PF02747 (Proliferating cell nuclear antigen, C-terminal domain) in Proliferating cell nuclear antigen. Showing 1 copy in chain E.

PF00705
Domain description: Proliferating cell nuclear antigen, N-terminal domain
Occurring in:
  1. Proliferating cell nuclear antigen
The deposited structure of PDB entry 6s1o contains 3 copies of Pfam domain PF00705 (Proliferating cell nuclear antigen, N-terminal domain) in Proliferating cell nuclear antigen. Showing 1 copy in chain E.

PF04081
Domain description: DNA polymerase delta, subunit 4
Occurring in:
  1. DNA polymerase delta subunit 4
The deposited structure of PDB entry 6s1o contains 1 copy of Pfam domain PF04081 (DNA polymerase delta, subunit 4 ) in DNA polymerase delta subunit 4. Showing 1 copy in chain D.

PF09507
Domain description: DNA polymerase subunit Cdc27
Occurring in:
  1. DNA polymerase delta subunit 3
The deposited structure of PDB entry 6s1o contains 1 copy of Pfam domain PF09507 (DNA polymerase subunit Cdc27) in DNA polymerase delta subunit 3. Showing 1 copy in chain C.

PF04042
Domain description: DNA polymerase alpha/epsilon subunit B
Occurring in:
  1. DNA polymerase delta subunit 2
The deposited structure of PDB entry 6s1o contains 1 copy of Pfam domain PF04042 (DNA polymerase alpha/epsilon subunit B) in DNA polymerase delta subunit 2. Showing 1 copy in chain B.

PF18018
Domain description: DNA polymerase delta subunit OB-fold domain
Occurring in:
  1. DNA polymerase delta subunit 2
The deposited structure of PDB entry 6s1o contains 1 copy of Pfam domain PF18018 (DNA polymerase delta subunit OB-fold domain) in DNA polymerase delta subunit 2. Showing 1 copy in chain B.

PF14260
Domain description: C4-type zinc-finger of DNA polymerase delta
Occurring in:
  1. DNA polymerase delta catalytic subunit
The deposited structure of PDB entry 6s1o contains 1 copy of Pfam domain PF14260 (C4-type zinc-finger of DNA polymerase delta) in DNA polymerase delta catalytic subunit. Showing 1 copy in chain A.

PF00136
Domain description: DNA polymerase family B
Occurring in:
  1. DNA polymerase delta catalytic subunit
The deposited structure of PDB entry 6s1o contains 1 copy of Pfam domain PF00136 (DNA polymerase family B) in DNA polymerase delta catalytic subunit. Showing 1 copy in chain A.

PF03104
Domain description: DNA polymerase family B, exonuclease domain
Occurring in:
  1. DNA polymerase delta catalytic subunit
The deposited structure of PDB entry 6s1o contains 1 copy of Pfam domain PF03104 (DNA polymerase family B, exonuclease domain) in DNA polymerase delta catalytic subunit. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000730
Domain description: Proliferating cell nuclear antigen, PCNA
Occurring in:
  1. Proliferating cell nuclear antigen
IPR022659
Domain description: Proliferating cell nuclear antigen, PCNA, conserved site
Occurring in:
  1. Proliferating cell nuclear antigen
IPR046938
Domain description: DNA clamp superfamily
Occurring in:
  1. Proliferating cell nuclear antigen
IPR006172
Domain description: DNA-directed DNA polymerase, family B
Occurring in:
  1. DNA polymerase delta catalytic subunit
IPR022649
Domain description: Proliferating cell nuclear antigen, PCNA, C-terminal
Occurring in:
  1. Proliferating cell nuclear antigen
IPR022648
Domain description: Proliferating cell nuclear antigen, PCNA, N-terminal
Occurring in:
  1. Proliferating cell nuclear antigen
IPR007218
Domain description: DNA polymerase delta, subunit 4
Occurring in:
  1. DNA polymerase delta subunit 4
IPR019038
Domain description: DNA polymerase delta subunit 3
Occurring in:
  1. DNA polymerase delta subunit 3
IPR041913
Domain description: DNA polymerase delta subunit 3 superfamily
Occurring in:
  1. DNA polymerase delta subunit 3
IPR041863
Domain description: DNA polymerase delta subunit 2, C-terminal domain
Occurring in:
  1. DNA polymerase delta subunit 2
IPR007185
Domain description: DNA polymerase alpha/delta/epsilon, subunit B
Occurring in:
  1. DNA polymerase delta subunit 2
IPR040663
Domain description: DNA polymerase delta subunit, OB-fold domain
Occurring in:
  1. DNA polymerase delta subunit 2
IPR024826
Domain description: DNA polymerase delta/II small subunit family
Occurring in:
  1. DNA polymerase delta subunit 2
IPR025687
Domain description: C4-type zinc-finger of DNA polymerase delta
Occurring in:
  1. DNA polymerase delta catalytic subunit
IPR042087
Domain description: DNA polymerase family B, thumb domain
Occurring in:
  1. DNA polymerase delta catalytic subunit
IPR017964
Domain description: DNA-directed DNA polymerase, family B, conserved site
Occurring in:
  1. DNA polymerase delta catalytic subunit
IPR023211
Domain description: DNA polymerase, palm domain superfamily
Occurring in:
  1. DNA polymerase delta catalytic subunit
IPR043502
Domain description: DNA/RNA polymerase superfamily
Occurring in:
  1. DNA polymerase delta catalytic subunit
IPR006134
Domain description: DNA-directed DNA polymerase, family B, multifunctional domain
Occurring in:
  1. DNA polymerase delta catalytic subunit
IPR036397
Domain description: Ribonuclease H superfamily
Occurring in:
  1. DNA polymerase delta catalytic subunit
IPR006133
Domain description: DNA-directed DNA polymerase, family B, exonuclease domain
Occurring in:
  1. DNA polymerase delta catalytic subunit
IPR012337
Domain description: Ribonuclease H-like superfamily
Occurring in:
  1. DNA polymerase delta catalytic subunit

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