EC 2.7.11.1: Non-specific serine/threonine protein kinase
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
- A-kinase
- AP50 kinase
- ATP-protein transphosphorylase
- Beta-IIPKC
- Beta-adrenergic receptor kinase
- CK-2
- CKI
- CKII
- Calcium-dependent protein kinase C
- Calcium/phospholipid-dependent protein kinase
- Casein kinase
- Casein kinase (phosphorylating)
- Casein kinase 2
- Casein kinase I
- Casein kinase II
- Cyclic AMP-dependent protein kinase
- Cyclic AMP-dependent protein kinase A
- Cyclic monophosphate-dependent protein kinase
- Cyclic nucleotide-dependent protein kinase
- Cyclin-dependent kinase
- Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
- Dsk1
- Epsilon PKC
- Glycogen synthase A kinase
- Glycogen synthase a kinase
- Glycogen synthase kinase
- HIPK2
- Hpr kinase
- Hydroxyalkyl-protein kinase
- M phase-specific cdc2 kinase
- MAPK
- Mitogen-activated S6 kinase
- Mitogen-activated protein kinase
- P82 kinase
- PKA
- PKC
- Phosphorylase B kinase kinase
- Phosphorylase b kinase kinase
- Phosphorylase b kinase kinase
- Protein glutamyl kinase
- Protein kinase (phosphorylating)
- Protein kinase A
- Protein kinase CK2
- Protein kinase p58
- Protein phosphokinase
- Protein serine kinase
- Protein serine-threonine kinase
- Protein-aspartyl kinase
- Protein-cysteine kinase
- Protein-serine kinase
- Prp4 protein kinase
- Raf kinase
- Raf-1
- Ribosomal S6 protein kinase
- Ribosomal protein S6 kinase II
- STK32
- Serine kinase
- Serine protein kinase
- Serine(threonine) protein kinase
- Serine-specific protein kinase
- Serine/threonine protein kinase
- T-antigen kinase
- Threonine-specific protein kinase
- Twitchin kinase
- Type-2 casein kinase
- WEE1Hu
- Wee 1-like kinase
- Wee-kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase A
- cGMP-dependent protein kinase
GO terms
Biochemical function:
- protein serine kinase activity
- potassium channel activator activity
- 14-3-3 protein binding
- phosphatidylinositol-3,4-bisphosphate binding
- protein homodimerization activity
- identical protein binding
- protein serine/threonine kinase inhibitor activity
- nitric-oxide synthase regulator activity
- protein kinase binding
- enzyme binding
- kinase activity
- phosphatidylinositol-3,4,5-trisphosphate binding
- ATP binding
- calmodulin binding
- protein binding
- protein serine/threonine/tyrosine kinase activity
- protein serine/threonine kinase activity
- protein kinase activity
Biological process:
- negative regulation of intrinsic apoptotic signaling pathway
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- negative regulation of lymphocyte migration
- regulation of type B pancreatic cell development
- positive regulation of protein localization to cell surface
- response to insulin-like growth factor stimulus
- cellular response to nerve growth factor stimulus
- positive regulation of protein localization to endoplasmic reticulum
- positive regulation of TORC1 signaling
- positive regulation of I-kappaB phosphorylation
- negative regulation of protein maturation
- positive regulation of protein localization to plasma membrane
- negative regulation of leukocyte cell-cell adhesion
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
- negative regulation of cilium assembly
- regulation of signal transduction by p53 class mediator
- cellular response to peptide
- positive regulation of protein localization to nucleus
- positive regulation of G1/S transition of mitotic cell cycle
- negative regulation of cGAS/STING signaling pathway
- negative regulation of protein localization to lysosome
- cellular response to oxidised low-density lipoprotein particle stimulus
- regulation of tRNA methylation
- regulation of postsynapse organization
- execution phase of apoptosis
- cellular response to granulocyte macrophage colony-stimulating factor stimulus
- negative regulation of release of cytochrome c from mitochondria
- cellular response to rapamycin
- maintenance of protein location in mitochondrion
- establishment of protein localization to mitochondrion
- negative regulation of protein serine/threonine kinase activity
- cellular response to prostaglandin E stimulus
- cellular response to epidermal growth factor stimulus
- cellular response to growth factor stimulus
- cellular response to tumor necrosis factor
- cellular response to cadmium ion
- response to growth factor
- response to UV-A
- labyrinthine layer blood vessel development
- glycogen cell differentiation involved in embryonic placenta development
- mammary gland epithelial cell differentiation
- response to growth hormone
- excitatory postsynaptic potential
- positive regulation of protein metabolic process
- striated muscle cell differentiation
- positive regulation of DNA-binding transcription factor activity
- positive regulation of nitric-oxide synthase activity
- positive regulation of smooth muscle cell proliferation
- behavioral response to pain
- insulin-like growth factor receptor signaling pathway
- positive regulation of lipid biosynthetic process
- protein autophosphorylation
- positive regulation of organ growth
- positive regulation of glucose import
- positive regulation of transcription by RNA polymerase II
- positive regulation of DNA-templated transcription
- negative regulation of proteolysis
- negative regulation of Notch signaling pathway
- positive regulation of cyclin-dependent protein serine/threonine kinase activity
- positive regulation of glycogen biosynthetic process
- positive regulation of fat cell differentiation
- positive regulation of nitric oxide biosynthetic process
- positive regulation of blood vessel endothelial cell migration
- phosphatidylinositol 3-kinase/protein kinase B signal transduction
- regulation of mRNA stability
- anoikis
- proteasome-mediated ubiquitin-dependent protein catabolic process
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of apoptotic process
- regulation of apoptotic process
- glucose homeostasis
- non-canonical NF-kappaB signal transduction
- cellular response to decreased oxygen levels
- cellular response to vascular endothelial growth factor stimulus
- interleukin-18-mediated signaling pathway
- intracellular signal transduction
- cellular response to reactive oxygen species
- response to fluid shear stress
- positive regulation of peptidyl-serine phosphorylation
- regulation of protein localization
- cellular response to insulin stimulus
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- peripheral nervous system myelin maintenance
- response to food
- negative regulation of protein binding
- positive regulation of endodeoxyribonuclease activity
- negative regulation of fatty acid beta-oxidation
- TOR signaling
- lipopolysaccharide-mediated signaling pathway
- regulation of myelination
- negative regulation of protein ubiquitination
- T cell costimulation
- positive regulation of cell migration
- regulation of cell migration
- positive regulation of cell growth
- protein catabolic process
- cell differentiation
- mammalian oogenesis stage
- cytokine-mediated signaling pathway
- virus-mediated perturbation of host defense response
- peptidyl-threonine phosphorylation
- peptidyl-serine phosphorylation
- protein ubiquitination
- phosphorylation
- negative regulation of macroautophagy
- regulation of neuron projection development
- negative regulation of endopeptidase activity
- positive regulation of glucose metabolic process
- positive regulation of sodium ion transport
- positive regulation of fibroblast migration
- fibroblast migration
- negative regulation of long-chain fatty acid import across plasma membrane
- negative regulation of gene expression
- positive regulation of gene expression
- positive regulation of endothelial cell migration
- negative regulation of autophagy
- gene expression
- obsolete response to organic substance
- response to hormone
- response to heat
- apoptotic mitochondrial changes
- insulin receptor signaling pathway
- cell population proliferation
- nervous system development
- germ cell development
- canonical NF-kappaB signal transduction
- G protein-coupled receptor signaling pathway
- epidermal growth factor receptor signaling pathway
- signal transduction
- response to oxidative stress
- inflammatory response
- activation-induced cell death of T cells
- apoptotic process
- nitric oxide biosynthetic process
- protein import into nucleus
- negative regulation of protein kinase activity
- protein phosphorylation
- regulation of translation
- glucose metabolic process
- regulation of glycogen biosynthetic process
- glycogen biosynthetic process
- glycogen metabolic process
- sphingosine-1-phosphate receptor signaling pathway
- cell migration involved in sprouting angiogenesis
- positive regulation of endothelial cell proliferation
- positive regulation of protein phosphorylation
- maternal placenta development
- osteoblast differentiation