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Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 1, in the presence of ssDNA

Source organism: Sulfolobus islandicus REY15A
Biochemical function: not assigned
Biological process: defense response to virus
Cellular component: cytoplasm

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF19021
Domain description: CRISPR system CMR subunit Cmr7 1
Occurring in:
  1. CRISPR-associated protein Cmrx
The deposited structure of PDB entry 6shb contains 26 copies of Pfam domain PF19021 (CRISPR system CMR subunit Cmr7 1) in CRISPR-associated protein Cmrx. Showing 1 copy in chain L.

PF03787
Domain description: RAMP superfamily
Occurring in:
  1. CRISPR-associated RAMP protein, Cmr4 family
  2. CRISPR-associated RAMP protein, Cmr6 family
  3. CRISPR-associated RAMP protein, Cmr1 family
The deposited structure of PDB entry 6shb contains 4 copies of Pfam domain PF03787 (RAMP superfamily) in CRISPR-associated RAMP protein, Cmr4 family. Showing 1 copy in chain D.
The deposited structure of PDB entry 6shb contains 1 copy of Pfam domain PF03787 (RAMP superfamily) in CRISPR-associated RAMP protein, Cmr6 family. Showing 1 copy in chain H [auth I].
The deposited structure of PDB entry 6shb contains 1 copy of Pfam domain PF03787 (RAMP superfamily) in CRISPR-associated RAMP protein, Cmr1 family. Showing 1 copy in chain I [auth J].

PF09700
Domain description: CRISPR-associated protein (Cas_Cmr3)
Occurring in:
  1. CRISPR-associated protein, Cmr3 family
The deposited structure of PDB entry 6shb contains 2 copies of Pfam domain PF09700 (CRISPR-associated protein (Cas_Cmr3)) in CRISPR-associated protein, Cmr3 family. Showing 2 copies in chain KA [auth H].

PF22335
Domain description: Cas10/Cmr2, second palm domain
Occurring in:
  1. CRISPR-associated protein, Cmr2 family

PF12469
Domain description: CRISPR-associated protein Cmr2, N-terminal
Occurring in:
  1. CRISPR-associated protein, Cmr2 family
The deposited structure of PDB entry 6shb contains 1 copy of Pfam domain PF12469 (CRISPR-associated protein Cmr2, N-terminal) in CRISPR-associated protein Cmr2 N-terminal domain-containing protein. Showing 1 copy in chain HA [auth K].

InterPro InterPro annotations
IPR043959
Domain description: CRISPR system CMR subunit Cmr7 1
Occurring in:
  1. CRISPR-associated protein Cmrx
IPR013410
Domain description: CRISPR-associated RAMP Cmr4
Occurring in:
  1. CRISPR-associated RAMP protein, Cmr4 family
IPR005537
Domain description: CRISPR type III-associated protein
Occurring in:
  1. CRISPR-associated RAMP protein, Cmr4 family
  2. CRISPR-associated RAMP protein, Cmr6 family
  3. CRISPR-associated RAMP protein, Cmr1 family
IPR023101
Domain description: AF1862-like domain superfamily
Occurring in:
  1. CRISPR type III-B/RAMP module-associated protein Cmr5
IPR010160
Domain description: CRISPR-associated protein, Cmr5
Occurring in:
  1. CRISPR type III-B/RAMP module-associated protein Cmr5
IPR010172
Domain description: CRISPR-associated protein, TM1791
Occurring in:
  1. CRISPR-associated RAMP protein, Cmr6 family
IPR019117
Domain description: CRISPR-associated protein, Cmr3
Occurring in:
  1. CRISPR-associated protein, Cmr3 family
IPR043128
Domain description: Reverse transcriptase/Diguanylate cyclase domain
Occurring in:
  1. CRISPR-associated protein, Cmr2 family
IPR024615
Domain description: CRISPR-associated protein Cmr2, N-terminal
Occurring in:
  1. CRISPR-associated protein, Cmr2 family
IPR013407
Domain description: CRISPR-associated protein Cmr2
Occurring in:
  1. CRISPR-associated protein, Cmr2 family
IPR038242
Domain description: CRISPR-Cas system, Cmr2 subunit, D1 domain, cysteine cluster
Occurring in:
  1. CRISPR-associated protein, Cmr2 family
IPR007522
Domain description: CRISPR-associated protein TM1795
Occurring in:
  1. CRISPR-associated RAMP protein, Cmr1 family
IPR010165
Domain description: Type III-B CRISPR module-associated protein Cmr3
Occurring in:
  1. CRISPR-associated protein, Cmr3 family

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