› 6snd

X-ray diffraction
3.1Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-209086 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
LN01 light chain Chains: A, L
Molecule details ›
Chains: A, L
Length: 213 amino acids
Theoretical weight: 23.23 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
LN01 heavy chain Chains: B, H
Molecule details ›
Chains: B, H
Length: 235 amino acids
Theoretical weight: 25.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Transmembrane protein gp41 Chains: C, P
Molecule details ›
Chains: C, P
Length: 25 amino acids
Theoretical weight: 3.29 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P04578 (Residues: 671-689; Coverage: 2%)
Gene name: env

Ligands and Environments

4 bound ligands:
Ligand NAG 2 x NAG
Ligand DPV 1 x DPV
Ligand PC 1 x PC
Ligand PSF 1 x PSF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P43212
Unit cell:
a: 137.707Å b: 137.707Å c: 146.719Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.238 0.267
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

12 review citations

Neutralizing Antibodies Targeting HIV-1 gp41.
Caillat et al. (2020)
11 more

3 mentions without citation

Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies.
Caillat et al. (2021)
2 more