› 6sne

X-ray diffraction
3.9Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-528586 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Transmembrane protein gp41 Chains: J, N, O, P
Molecule details ›
Chains: J, N, O, P
Length: 63 amino acids
Theoretical weight: 7.48 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P04578 (Residues: 649-711; Coverage: 8%)
Gene name: env
Sequence domains: Retroviral envelope protein
LN01 light chain Chains: A, C, E, L
Molecule details ›
Chains: A, C, E, L
Length: 214 amino acids
Theoretical weight: 23.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
LN01 heavy chain Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 235 amino acids
Theoretical weight: 25.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

2 bound ligands:
Ligand NAG 4 x NAG
Ligand PC 10 x PC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P212121
Unit cell:
a: 65.686Å b: 144.644Å c: 409.405Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.218 0.261
Expression systems:
  • Escherichia coli K-12
  • Homo sapiens

Quick links

Citations

13 review citations

Broadly Neutralizing Antibodies for HIV-1 Prevention.
Walsh et al. (2021)
12 more

2 mentions without citation

Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01.
Pinto et al. (2019)
1 more