› 6swa

Electron Microscopy
3.1Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 46-mer (preferred)
PDBe Complex ID:
PDB-CPX-517737 (preferred)
Entry contents:
43 distinct polypeptide molecules
3 distinct RNA molecules
Macromolecules (46 distinct):
Large ribosomal subunit protein uL2 Chain: A
Molecule details ›
Chain: A
Length: 252 amino acids
Theoretical weight: 27.46 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P62918 (Residues: 2-253; Coverage: 98%)
Gene name: Rpl8
Sequence domains:
Large ribosomal subunit protein uL3 Chain: B
Molecule details ›
Chain: B
Length: 394 amino acids
Theoretical weight: 45.22 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P27659 (Residues: 2-395; Coverage: 98%)
Gene name: Rpl3
Sequence domains: Ribosomal protein L3
Large ribosomal subunit protein uL4 Chain: C
Molecule details ›
Chain: C
Length: 363 amino acids
Theoretical weight: 41.32 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9D8E6 (Residues: 3-365; Coverage: 87%)
Gene name: Rpl4
Sequence domains:
Large ribosomal subunit protein uL18 Chain: D
Molecule details ›
Chain: D
Length: 294 amino acids
Theoretical weight: 34.13 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P47962 (Residues: 4-297; Coverage: 99%)
Gene name: Rpl5
Sequence domains:
Large ribosomal subunit protein eL6 Chain: E
Molecule details ›
Chain: E
Length: 194 amino acids
Theoretical weight: 22.36 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P47911 (Residues: 103-296; Coverage: 66%)
Gene name: Rpl6
Sequence domains: Ribosomal protein L6e
Large ribosomal subunit protein uL30 Chain: F
Molecule details ›
Chain: F
Length: 234 amino acids
Theoretical weight: 27.67 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P14148 (Residues: 37-270; Coverage: 87%)
Gene name: Rpl7
Sequence domains:
Large ribosomal subunit protein eL8 Chain: G
Molecule details ›
Chain: G
Length: 234 amino acids
Theoretical weight: 26.71 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P12970 (Residues: 29-262; Coverage: 88%)
Gene names: Rpl7a, Surf-3, Surf3
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein uL6 Chain: H
Molecule details ›
Chain: H
Length: 191 amino acids
Theoretical weight: 21.79 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P51410 (Residues: 1-191; Coverage: 100%)
Gene name: Rpl9
Sequence domains: Ribosomal protein L6
Large ribosomal subunit protein uL16 Chain: I
Molecule details ›
Chain: I
Length: 211 amino acids
Theoretical weight: 24.38 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q6ZWV3 (Residues: 3-213; Coverage: 99%)
Gene names: Qm, Rpl10
Sequence domains: Ribosomal protein L16p/L10e
Large ribosomal subunit protein uL5 Chain: J
Molecule details ›
Chain: J
Length: 169 amino acids
Theoretical weight: 19.27 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9CXW4 (Residues: 9-177; Coverage: 95%)
Gene name: Rpl11
Sequence domains:
Large ribosomal subunit protein eL13 Chain: K
Molecule details ›
Chain: K
Length: 205 amino acids
Theoretical weight: 23.62 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P47963 (Residues: 2-206; Coverage: 97%)
Gene name: Rpl13
Sequence domains: Ribosomal protein L13e
Large ribosomal subunit protein eL14 Chain: L
Molecule details ›
Chain: L
Length: 139 amino acids
Theoretical weight: 16.3 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9CR57 (Residues: 2-140; Coverage: 64%)
Gene name: Rpl14
Sequence domains: Ribosomal protein L14
Large ribosomal subunit protein eL15 Chain: M
Molecule details ›
Chain: M
Length: 203 amino acids
Theoretical weight: 24.08 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9CZM2 (Residues: 2-204; Coverage: 100%)
Gene name: Rpl15
Sequence domains: Ribosomal L15
Large ribosomal subunit protein uL13 Chain: N
Molecule details ›
Chain: N
Length: 195 amino acids
Theoretical weight: 22.75 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P19253 (Residues: 5-199; Coverage: 96%)
Gene names: P198, Rpl13a, Tstap198-7
Sequence domains: Ribosomal protein L13
Large ribosomal subunit protein uL22 Chain: O
Molecule details ›
Chain: O
Length: 153 amino acids
Theoretical weight: 17.76 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9CPR4 (Residues: 2-154; Coverage: 83%)
Gene name: Rpl17
Sequence domains: Ribosomal protein L22p/L17e
Large ribosomal subunit protein eL18 Chain: P
Molecule details ›
Chain: P
Length: 185 amino acids
Theoretical weight: 21.41 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P35980 (Residues: 4-188; Coverage: 98%)
Gene name: Rpl18
Sequence domains: Ribosomal protein 60S L18 and 50S L18e
Large ribosomal subunit protein eL20 Chain: Q
Molecule details ›
Chain: Q
Length: 175 amino acids
Theoretical weight: 20.63 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P62717 (Residues: 1-175; Coverage: 99%)
Gene name: Rpl18a
Sequence domains: Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
Large ribosomal subunit protein eL21 Chain: R
Molecule details ›
Chain: R
Length: 157 amino acids
Theoretical weight: 18.27 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: O09167 (Residues: 2-158; Coverage: 98%)
Gene name: Rpl21
Sequence domains: Ribosomal protein L21e
Large ribosomal subunit protein eL22 Chain: S
Molecule details ›
Chain: S
Length: 101 amino acids
Theoretical weight: 11.74 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P67984 (Residues: 16-116; Coverage: 79%)
Gene name: Rpl22
Sequence domains: Ribosomal L22e protein family
Large ribosomal subunit protein uL14 Chain: T
Molecule details ›
Chain: T
Length: 129 amino acids
Theoretical weight: 13.83 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P62830 (Residues: 12-140; Coverage: 92%)
Gene name: Rpl23
Sequence domains: Ribosomal protein L14p/L23e
Large ribosomal subunit protein eL24 Chain: U
Molecule details ›
Chain: U
Length: 62 amino acids
Theoretical weight: 7.38 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q8BP67 (Residues: 2-63; Coverage: 40%)
Gene name: Rpl24
Sequence domains: Ribosomal protein L24e
Large ribosomal subunit protein uL23 Chain: V
Molecule details ›
Chain: V
Length: 118 amino acids
Theoretical weight: 13.73 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P62751 (Residues: 39-156; Coverage: 76%)
Gene name: Rpl23a
Sequence domains:
Large ribosomal subunit protein uL24 Chain: W
Molecule details ›
Chain: W
Length: 127 amino acids
Theoretical weight: 15.16 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q4FZH2 (Residues: 1-127; Coverage: 88%)
Gene name: Rpl26
Sequence domains:
60S ribosomal protein L27 Chain: X
Molecule details ›
Chain: X
Length: 134 amino acids
Theoretical weight: 15.65 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q5BLJ9 (Residues: 3-136; Coverage: 99%)
Gene name: Rpl27
Sequence domains:
Large ribosomal subunit protein uL15 Chain: Y
Molecule details ›
Chain: Y
Length: 147 amino acids
Theoretical weight: 16.52 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P14115 (Residues: 2-148; Coverage: 99%)
Gene name: Rpl27a
Sequence domains: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Large ribosomal subunit protein eL29 Chain: Z
Molecule details ›
Chain: Z
Length: 68 amino acids
Theoretical weight: 7.96 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P47915 (Residues: 2-69; Coverage: 43%)
Gene names: Rpl29, Rpl43
Sequence domains: Ribosomal L29e protein family
Large ribosomal subunit protein eL30 Chain: a
Molecule details ›
Chain: a
Length: 97 amino acids
Theoretical weight: 10.81 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P62889 (Residues: 13-109; Coverage: 84%)
Gene name: Rpl30
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein eL31 Chain: b
Molecule details ›
Chain: b
Length: 106 amino acids
Theoretical weight: 12.51 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P62900 (Residues: 18-123; Coverage: 85%)
Gene name: Rpl31
Sequence domains: Ribosomal protein L31e
Large ribosomal subunit protein eL32 Chain: c
Molecule details ›
Chain: c
Length: 129 amino acids
Theoretical weight: 15.18 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P62911 (Residues: 2-130; Coverage: 96%)
Gene name: Rpl32
Sequence domains: Ribosomal protein L32
Large ribosomal subunit protein eL33 Chain: d
Molecule details ›
Chain: d
Length: 109 amino acids
Theoretical weight: 12.45 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: O55142 (Residues: 2-110; Coverage: 99%)
Gene name: Rpl35a
Sequence domains: Ribosomal protein L35Ae
Large ribosomal subunit protein eL34 Chain: e
Molecule details ›
Chain: e
Length: 114 amino acids
Theoretical weight: 12.99 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9D1R9 (Residues: 2-115; Coverage: 97%)
Gene name: Rpl34
Sequence domains: Ribosomal protein L34e
Large ribosomal subunit protein uL29 Chain: f
Molecule details ›
Chain: f
Length: 122 amino acids
Theoretical weight: 14.46 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q6ZWV7 (Residues: 2-123; Coverage: 99%)
Gene name: Rpl35
Sequence domains: Ribosomal L29 protein
Large ribosomal subunit protein eL36 Chain: g
Molecule details ›
Chain: g
Length: 98 amino acids
Theoretical weight: 11.49 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P47964 (Residues: 4-101; Coverage: 93%)
Gene name: Rpl36
Sequence domains: Ribosomal protein L36e
Large ribosomal subunit protein eL37 Chain: h
Molecule details ›
Chain: h
Length: 84 amino acids
Theoretical weight: 9.86 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9D823 (Residues: 2-85; Coverage: 87%)
Gene name: Rpl37
Sequence domains: Ribosomal protein L37e
Large ribosomal subunit protein eL38 Chain: i
Molecule details ›
Chain: i
Length: 69 amino acids
Theoretical weight: 8.09 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9JJI8 (Residues: 2-70; Coverage: 99%)
Gene name: Rpl38
Sequence domains: Ribosomal L38e protein family
Large ribosomal subunit protein eL39 Chain: j
Molecule details ›
Chain: j
Length: 50 amino acids
Theoretical weight: 6.3 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q505A8 (Residues: 2-51; Coverage: 98%)
Gene name: Rpl39
Sequence domains: Ribosomal L39 protein
Ubiquitin-ribosomal protein eL40 fusion protein Chain: k
Molecule details ›
Chain: k
Length: 50 amino acids
Theoretical weight: 5.96 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q5M9K3 (Residues: 78-127; Coverage: 39%)
Gene name: Uba52
Sequence domains: Ribosomal L40e family
Small ribosomal subunit protein eS32 Chain: l
Molecule details ›
Chain: l
Length: 25 amino acids
Theoretical weight: 3.47 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P62947 (Residues: 1-25; Coverage: 100%)
Gene name: Rpl41
Sequence domains: Ribosomal protein L41
Large ribosomal subunit protein eL42 Chain: m
Molecule details ›
Chain: m
Length: 105 amino acids
Theoretical weight: 12.35 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q5M9P1 (Residues: 2-106; Coverage: 99%)
Gene name: Rpl36a
Sequence domains: Ribosomal protein L44
Ribosomal protein L37a Chain: n
Molecule details ›
Chain: n
Length: 91 amino acids
Theoretical weight: 10.17 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q4VAF2 (Residues: 2-92; Coverage: 99%)
Gene name: Rpl37a
Sequence domains: Ribosomal L37ae protein family
Large ribosomal subunit protein eL19 Chain: o
Molecule details ›
Chain: o
Length: 184 amino acids
Theoretical weight: 22.1 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P84099 (Residues: 2-185; Coverage: 94%)
Gene name: Rpl19
Sequence domains: Ribosomal protein L19e
Large ribosomal subunit protein eL28 Chain: p
Molecule details ›
Chain: p
Length: 122 amino acids
Theoretical weight: 14.01 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P41105 (Residues: 2-123; Coverage: 89%)
Gene name: Rpl28
Sequence domains: Ribosomal L28e protein family
Proliferation-associated protein 2G4 Chain: t
Molecule details ›
Chain: t
Length: 353 amino acids
Theoretical weight: 39.39 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P50580 (Residues: 8-360; Coverage: 90%)
Gene names: Ebp1, Pa2g4, Plfap
Sequence domains: Metallopeptidase family M24
28S ribosomal RNA Chain: q
Molecule details ›
Chain: q
Length: 3612 nucleotides
Theoretical weight: 1170.2 KDa
Sequence domains: Eukaryotic large subunit ribosomal RNA
5.8S ribosomal RNA Chain: r
Molecule details ›
Chain: r
Length: 157 nucleotides
Theoretical weight: 50.45 KDa
Sequence domains: 5.8S ribosomal RNA
5S ribosomal RNA Chain: s
Molecule details ›
Chain: s
Length: 119 nucleotides
Theoretical weight: 38.39 KDa
Sequence domains: 5S ribosomal RNA

Ligands and Environments

2 bound ligands:
Ligand MG 247 x MG
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-10321

Quick links

Citations

4 review citations

Ribosome biogenesis factors-from names to functions.
Dörner et al. (2023)
3 more

3 mentions without citation

Protein Synthesis in the Developing Neocortex at Near-Atomic Resolution Reveals Ebp1-Mediated Neuronal Proteostasis at the 60S Tunnel Exit.
Kraushar et al. (2021)
2 more