› 6swp

X-ray diffraction
1.6Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-540967 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 2 Chain: AAA
Molecule details ›
Chain: AAA
Length: 115 amino acids
Theoretical weight: 13.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25440 (Residues: 344-455; Coverage: 14%)
Gene names: BRD2, KIAA9001, RING3
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:
Ligand EDO 2 x EDO
Ligand LW5 1 x LW5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P21212
Unit cell:
a: 72.201Å b: 52.39Å c: 32.024Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.156 0.154 0.193
Expression system: Escherichia coli

Quick links

Citations

48 review citations

Achieving clinical success with BET inhibitors as anti-cancer agents.
Shorstova et al. (2021)
47 more

1 mention without citation

Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation.
Gilan et al. (2020)