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Crystal structure of the accessory translocation ATPase, SecA2, from Clostridium difficile, in complex with adenosine-5'-(gamma-thio)-triphosphate

Source organism: Clostridioides difficile 630
Biochemical function: protein-exporting ATPase activity
Biological process: intracellular protein transmembrane transport
Cellular component: cell envelope Sec protein transport complex

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EC 7.4.2.8: Protein-secreting ATPase

Reaction catalysed:
ATP + H(2)O + cellular protein(Side 1) = ADP + phosphate + cellular protein(Side 2)
Systematic name:
ATP phosphohydrolase (protein-secreting)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF21090
Domain description: SecA P-loop domain
Occurring in:
  1. Protein translocase subunit SecA 2
The deposited structure of PDB entry 6t4h contains 2 copies of Pfam domain PF21090 (SecA P-loop domain) in Protein translocase subunit SecA 2. Showing 2 copies in chain A.

PF07516
Domain description: SecA Wing and Scaffold domain
Occurring in:
  1. Protein translocase subunit SecA 2
The deposited structure of PDB entry 6t4h contains 1 copy of Pfam domain PF07516 (SecA Wing and Scaffold domain) in Protein translocase subunit SecA 2. Showing 1 copy in chain A.

PF01043
Domain description: SecA preprotein cross-linking domain
Occurring in:
  1. Protein translocase subunit SecA 2
The deposited structure of PDB entry 6t4h contains 1 copy of Pfam domain PF01043 (SecA preprotein cross-linking domain) in Protein translocase subunit SecA 2. Showing 1 copy in chain A.

PF07517
Domain description: SecA DEAD-like domain
Occurring in:
  1. Protein translocase subunit SecA 2
The deposited structure of PDB entry 6t4h contains 1 copy of Pfam domain PF07517 (SecA DEAD-like domain) in Protein translocase subunit SecA 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000185
Domain description: Protein translocase subunit SecA
Occurring in:
  1. Protein translocase subunit SecA 2
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Protein translocase subunit SecA 2
IPR001650
Domain description: Helicase, C-terminal domain-like
Occurring in:
  1. Protein translocase subunit SecA 2
IPR011130
Domain description: SecA, preprotein cross-linking domain
Occurring in:
  1. Protein translocase subunit SecA 2
IPR011115
Domain description: SecA DEAD-like, N-terminal
Occurring in:
  1. Protein translocase subunit SecA 2
IPR036266
Domain description: SecA, Wing/Scaffold superfamily
Occurring in:
  1. Protein translocase subunit SecA 2
IPR011116
Domain description: SecA Wing/Scaffold
Occurring in:
  1. Protein translocase subunit SecA 2
IPR020937
Domain description: SecA conserved site
Occurring in:
  1. Protein translocase subunit SecA 2
IPR044722
Domain description: SecA, C-terminal helicase domain
Occurring in:
  1. Protein translocase subunit SecA 2
IPR036670
Domain description: SecA, preprotein cross-linking domain superfamily
Occurring in:
  1. Protein translocase subunit SecA 2
IPR014001
Domain description: Helicase superfamily 1/2, ATP-binding domain
Occurring in:
  1. Protein translocase subunit SecA 2
IPR014018
Domain description: SecA motor DEAD
Occurring in:
  1. Protein translocase subunit SecA 2

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