› 6t5v

X-ray diffraction
1.31Å resolution

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133991 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTPase KRas, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 19.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01116 (Residues: 1-169; Coverage: 89%)
  • Best match: P01116-2 (Residues: 1-169)
Gene names: KRAS, KRAS2, RASK2
Sequence domains: Ras family

Ligands and Environments

3 bound ligands:
Ligand MG 1 x MG
Ligand GDP 1 x GDP
Ligand MKZ 1 x MKZ
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 40.421Å b: 51.135Å c: 90.186Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.177 0.205
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Inhibition of Nonfunctional Ras.
Nussinov et al. (2021)
3 more

2 mentions without citation

Drugging the undruggable: a computational chemist's view of KRASG12C.
Bodnarchuk et al. (2021)
1 more

PDB-REDO

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