› 6t7z

X-ray diffraction
2Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171933 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Kelch-like ECH-associated protein 1 Chain: A
Molecule details ›
Chain: A
Length: 293 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14145 (Residues: 321-609; Coverage: 46%)
Gene names: INRF2, KEAP1, KIAA0132, KLHL19
Sequence domains: Kelch motif
ACE-CYS-ASA-4FB-GLU-THR-GLY-GLU-CYS-NH2 Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 895 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ACT 4 x ACT
1 modified residue:
Ligand 4FB 1 x 4FB

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P3221
Unit cell:
a: 75.153Å b: 75.153Å c: 114.51Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.222 0.257
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

5 review citations

Nrf2/Keap1/ARE signaling: Towards specific regulation.
Ulasov et al. (2022)
4 more