› 6tbt

X-ray diffraction
1.63Å resolution

Crystal structure of the BCL6 BTB domain in complex with an Apt48 peptide

Released:
DOI: 10.2210/pdb6tbt/pdb
PDB entry 6tbt coloured by chain, front view.
PDB entry 6tbt coloured by chain, side view.
PDB entry 6tbt coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of Apt48 inhibition of the BCL6 BTB domain.
Zacharchenko T, Kalverda AP, Wright SC
Structure 30 396-407.e3 (2022)
PMID: 34774129

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154266 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
B-cell lymphoma 6 protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 126 amino acids
Theoretical weight: 14.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P41182 (Residues: 6-129; Coverage: 18%)
Gene names: BCL5, BCL6, LAZ3, ZBTB27, ZNF51
Sequence domains: BTB/POZ domain
Apt48 peptide Chains: C, D
Molecule details ›
Chains: C, D
Length: 14 amino acids
Theoretical weight: 1.5 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

4 bound ligands:
Ligand CL 5 x CL
Ligand MG 2 x MG
Ligand GOL 1 x GOL
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P3121
Unit cell:
a: 65.63Å b: 65.63Å c: 156.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.154 0.153 0.178
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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