› 6tcg

Solution NMR

2'-F-riboguanosine and 2'-F-arabinoguanosine modified G-quadruplex with V-loop and all-syn G-tract

Released:
DOI: 10.2210/pdb6tcg/pdb
PDB entry 6tcg coloured by chain, ensemble of 10 models, front view.
PDB entry 6tcg coloured by chain, ensemble of 10 models, side view.
PDB entry 6tcg coloured by chain, ensemble of 10 models, top view.
Source organism: synthetic construct
Primary publication:
Switching the type of V-loop in sugar-modified G-quadruplexes through altered fluorine interactions.
Haase L, Weisz K
Chem Commun (Camb) 56 4539-4542 (2020)
PMID: 32202271

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-120646 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*GP*GP*GP*AP*TP*GP*GP*GP*AP*CP*AP*CP*AP*(GF2)P*(GFL)P*GP*GP*AP*CP*GP*GP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 22 nucleotides
Theoretical weight: 7.01 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
2 modified residues:
Ligand GF2 1 x GF2
Ligand GFL 1 x GFL

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 34%
Refinement method: molecular dynamics
Expression system: Not provided

Quick links

Citations

1 review citation

Structural motifs and intramolecular interactions in non-canonical G-quadruplexes.
Jana et al. (2021)
2 other articles

2 mentions without citation

Locked nucleic acid building blocks as versatile tools for advanced G-quadruplex design.
Haase et al. (2020)
1 more