› 6ti5

Solid-state NMR

A New Structural Model of Abeta(1-40) Fibrils

Released:
DOI: 10.2210/pdb6ti5/pdb
PDB entry 6ti5 coloured by chain, ensemble of 4 models, front view.
PDB entry 6ti5 coloured by chain, ensemble of 4 models, side view.
PDB entry 6ti5 coloured by chain, ensemble of 4 models, top view.
Source organism: Homo sapiens
Primary publication:
Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils.
Cerofolini L, Ravera E, Bologna S, Wiglenda T, Böddrich A, Purfürst B, Benilova I, Korsak M, Gallo G, Rizzo D, Gonnelli L, Fragai M, De Strooper B, Wanker EE, Luchinat C
Chem Commun (Camb) 56 8830-8833 (2020)
PMID: 32749391

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138393 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 40 Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Length: 40 amino acids
Theoretical weight: 4.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05067 (Residues: 672-711; Coverage: 5%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 2%
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Interpretable artificial intelligence and exascale molecular dynamics simulations to reveal kinetics: Applications to Alzheimer's disease.
Martin et al. (2022)
1 more

8 mentions without citation

Amyloid Cross-Seeding: Mechanism, Implication, and Inhibition.
Subedi et al. (2022)
7 more