› 6toi

X-ray diffraction
1.58Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154271 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
B-cell lymphoma 6 protein Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 14.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P41182 (Residues: 5-129; Coverage: 18%)
Gene names: BCL5, BCL6, LAZ3, ZBTB27, ZNF51
Sequence domains: BTB/POZ domain
ALA-TRP-VAL-ILE-PRO-ALA Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 656 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand NQN 1 x NQN
Ligand EDO 5 x EDO
Ligand DMS 2 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P6122
Unit cell:
a: 67.66Å b: 67.66Å c: 166.64Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.164 0.163 0.184
Expression systems:
  • Escherichia coli BL21
  • Not provided

Quick links

Citations

6 review citations

Advances in targeting 'undruggable' transcription factors with small molecules.
Henley et al. (2021)
5 more

1 mention without citation

Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.
Bellenie et al. (2020)