› 6tsg

X-ray diffraction
2.98Å resolution

Crystal structure of Peroxisome proliferator-activated receptor gamma (PPARG) in complex with TETRAC

Released:
DOI: 10.2210/pdb6tsg/pdb
PDB entry 6tsg coloured by chain, front view.
PDB entry 6tsg coloured by chain, side view.
PDB entry 6tsg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPARγ.
Gellrich L, Heitel P, Heering J, Kilu W, Pollinger J, Goebel T, Kahnt A, Arifi S, Pogoda W, Paulke A, Steinhilber D, Proschak E, Wurglics M, Schubert-Zsilavecz M, Chaikuad A, Knapp S, Bischoff I, Fürst R, Merk D
J Med Chem 63 6727-6740 (2020)
PMID: 32356658

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 277 amino acids
Theoretical weight: 31.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 231-505; Coverage: 55%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:
Ligand T4A 1 x T4A
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P41212
Unit cell:
a: 61.678Å b: 61.678Å c: 166.487Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.236 0.292
Expression system: Escherichia coli BL21(DE3)

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Citations

7 citation in other articles

Heterodimer formation with retinoic acid receptor RXRα modulates coactivator recruitment by peroxisome proliferator-activated receptor PPARγ.
Kilu et al. (2021)
6 more

3 mentions without citation

Utilizing Bioinformatics Technology to Explore the Potential Mechanism of Danggui Buxue Decoction against NSCLC.
Yu et al. (2022)
2 more