› 6twr

Solution NMR

Structure of a constitutively active CAT-PRD1 mutant of the antiterminator LicT protein.

Released:
DOI: 10.2210/pdb6twr/pdb
PDB entry 6twr coloured by chain, ensemble of 20 models, front view.
PDB entry 6twr coloured by chain, ensemble of 20 models, side view.
PDB entry 6twr coloured by chain, ensemble of 20 models, top view.
Source organism: Bacillus subtilis
Primary publication:
Resolving the activation mechanism of the D99N antiterminator LicT protein.
Yang Y, Gracy J, Declerck N, Déméné H
J Struct Biol 213 107730 (2021)
PMID: 33781896

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153957 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription antiterminator LicT Chains: A, B
Molecule details ›
Chains: A, B
Length: 175 amino acids
Theoretical weight: 19.94 KDa
Source organism: Bacillus subtilis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P39805 (Residues: 1-167; Coverage: 60%)
Gene names: BSU39080, N15A, licT
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 35%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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Citations

1 mention without citation

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Scott et al. (2021)